Ophthalmology - Dômes Pharma 2025

Eye protection with lubricants and advanced BioHAnceTM technology

Managing dry eyes in dogs: a comprehensive guide for vets

 

Understanding causes, symptoms and treatments.

 

Read the article

Dômes Pharma launches its range of corneal protectors for dogs, cats, horses and exotics in Canada: REMEND™ 0.4, REMEND™ 0.75 & OCRY-GEL™.

 

REMEND™ products are manufactured using a patented hyaluronic acid cross-linking technology, BioHance™ technology.

 

 

BioHAnce™ is a patented technology which uses advanced bioengineering to create a molecular matrix of cross-linked hyaluronic acid. It produces a molecular scaffolding with unique physical and chemical properties, that enhances hydration, accelerates the body’s own healing processes and extends duration on ocular surface.

BioHAnce™ cross-linked hyaluronic acid has many benefits:

  • Enhances hydration, lubrication, ocular comfort and helps stabilize the tear film1
  • Increases residence time (vs linear hyaluronic acid): lasts 2-5 times longer than traditional artificial tears2,3
  • Requires less applications (twice a day), thus improving compliance
  • Creates a thin barrier that soothes and protects the eye without altering vision
  • 0.75% BioHAnce™ cross-linked hyaluronic acid supports faster corneal reconstruction (vs linear hyaluronic acid): up to 34%4
  • Prolongs the presence of topical treatments on the ocular surface5
  • Very good tolerance:
    - Preservative free
    - Thiol cross-linking allows for a purified end product (no residual crosslinker which can be irritating or cause inflammation)

REMEND™ 0.4 - Lubricate and defend the cornea in case of dry or irritated eyes

  • 1-2 drops per eye twice a day
  • 10ml bottle = provides around 30 days of use
  • Shelf life after opening = 1 month

REMEND™ 0.75 - Support natural corneal regeneration

  • 1-2 drops per eye twice a day onto the affected eye until corneal reepithelialization is achieved
  • 3 ml bottle = provides around 15 days of use
  • Shelf life after opening = 1 month

OCRY-GEL™ - Provide lubrication and hydration during situations of sedation, anesthesia or corneal exposure

  • Ergonomic nozzle
  • No white streaks upon drying
  • 0.5-1 cm spread over the corneal surface on average twice a day or as necessary.
  • Shelf life after opening = 1 month

Reference 

  1. Plummer CE, Martins BC, Bolch C, Martinez PS, Carbia BE (2022). Evaluation of topically applied cross-linked hyaluronic acid (Remend™) on the ocular surface of clinically healthy dogs. College of Veterinary Medicine, University of Florida; School of Veterinary Medicine, University of California- Davis; Institute for Vision Research, University of Florida. ACVO 2022.   
  2. Montiani-Ferreira F, Atzet SK, Fankhauser AD, Behan EK, Haeussler DJ (2022). Fluorometric evaluation of cross-linked vs linear hyaluronic acid eye lubricants. SentrX Animal Care; Veterinary Medicine Department, Federal University of Paraná; Animal Eye Institute. ACVO 2022. 
  3. Bedos L, Allbaugh RA, Roy MM, Kubai MA, Sebbag L. Precorneal retention time of ocular lubricants in dogs. Iowa State University College of Veterinary Medicine; Koret Schoolof Veterinary Medicine, The Hebrew University of Jerusalem.
  4. Williams DL, Wirostko BM,Gum G, Mann BK (2017). Topical cross-linked HA-based hydrogel accelerates closure of corneal epithelial defects and repair of stromal ulceration in companion animals. Invest Ophthalmol Vis Sci. ; 58:4616–4622. 
  5. Sebbag L, Ortaeskinaz E, Goncharov Y, Ofri R, Arad D. (2023) Cross-linked hyaluronic acid enhances tear film concentrations of cefazolin sodium in canine eyes. Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel - ACVO Thursday, September 21st, 2023.